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This paper proposes an integrated potentiostat circuit to realize a compact, power-efficient, and cost-efficient biosensor driving circuit. The proposed potentiostat consists of two integrated operational amplifiers, each of which can be configured with negative feedback to perform potentiostat functionality. When configured as a potentiostat, the control operational amplifier controls the voltage of the counter electrode of the sensor to make the voltage difference between the reference and the working electrodes of the sensor to be identical to the input voltage fed by an external digital-to-analog converter. The other operational amplifier is configured as a transimpedance amplifier which converts the sensing current to the voltage, which is digitally converted by an external analog-to-digital converter. In the experiment, the proposed potentiostat is assembled with digital-to-analog converters, analog-to-digital converters, control-logics, and a laptop computer to form a portable and low-cost bio-sensor platform. With this platform enabled by our chip, users can easily and cost-efficiently generate the necessary control signals such as cyclic waves for bio-sensors.